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Publications

Automated Identification of Heart Failure With Reduced Ejection Fraction Using Deep Learning-Based Natural Language Processing

Arash A. Nargesi, Philip Adejumo, Lovedeep Singh Dhingra, Benjamin Rosand, Astrid Hengartner, Andreas Coppi, Simon Benigeri, Sounok Sen, Tariq Ahmad, Girish N. Nadkarni, Zhenqiu Lin, Faraz S. Ahmad, Harlan M. Krumholz, Rohan Khera

JACC: Heart Failure. October 2024.

Cardiovascular care with digital twin technology in the era of generative artificial intelligence

Phyllis M Thangaraj, Sean H Benson, Evangelos K Oikonomou, Folkert W Asselbergs, Rohan Khera

European Heart Journal. September 2024.

Artificial Intelligence-Enhanced Risk Stratification of Cancer Therapeutics-Related Cardiac Dysfunction Using Electrocardiographic Images

Evangelos K. Oikonomou, Veer Sangha, Lovedeep S. Dhingra, Arya Aminorroaya, Andreas Coppi, Harlan M. Krumholz, Lauren A. Baldassarre, and Rohan Khera

Circulation: Cardiovascular Quality and Outcomes. September 2024.

Correlation between hospital rates of survival to discharge and long-term survival for in-hospital cardiac arrest: Insights from Get With The Guidelines®-Resuscitation registry

Rohan Khera, Arya Aminorroaya, Kevin F. Kennedy, Paul S. Chan

Resuscitation. September 2024.

Efficient deep learning-based automated diagnosis from echocardiography with contrastive self-supervised learning

Gregory Holste, Evangelos K. Oikonomou, Bobak J. Mortazavi, Zhangyang Wang & Rohan Khera

Communications Medicine. July 2024.

Artificial intelligence-enhanced patient evaluation: bridging art and science

Evangelos K Oikonomou, Rohan Khera

European Heart Journal. July 2024.

Leveraging the Full Potential of Wearable Devices in Cardiomyopathies

Evangelos K Oikonomou, Rohan Khera

Journal of Cardiac Failure. July 2024.

Transforming Cardiovascular Care With Artificial Intelligence: From Discovery to Practice

Khera R, Oikonomou EK, Nadkarni GN, Morley JR, Wiens J, Butte AJ, Topol EJ

Journal of the American College of Cardiology. July 2024.

Designing medical artificial intelligence systems for global use: focus on interoperability, scalability, and accessibility

Oikonomou EK, Khera R

Hellenic Journal of Cardiology. July 2024.

Performance of contemporary cardiovascular risk stratification scores in Brazil: an evaluation in the ELSA-Brasil study

Aline Pedroso Camargos, Sandhi Barreto, Luisa Brant, Antonio Luiz P Ribeiro, Lovedeep S Dhingra, Arya Aminorroaya, Marcio Bittencourt, Roberta C Figueiredo, Rohan Khera

Open Heart BMJ. June 2024.

Video-Based Kinematic Analysis of Movement Quality in a Phase 3 Clinical Trial of Troriluzole in Adults with Spinocerebellar Ataxia: A Post Hoc Analysis

Gilbert J. L’Italien, Evangelos K. Oikonomou, Rohan Khera, Michele H. Potashman, Melissa W. Beiner, Grant D. H. Maclaine, Jeremy D. Schmahmann, Susan Perlman & Vladimir Coric

Neurology and Therapy. May 2024.

Development and multinational validation of an algorithmic strategy for high Lp(a) screening

Arya Aminorroaya, Lovedeep S. Dhingra, Evangelos K. Oikonomou, Seyedmohammad Saadatagah, Phyllis Thangaraj, Sumukh Vasisht Shankar, Erica S. Spatz & Rohan Khera

Nature Cardiovascular Research. May 2024.

Biometric contrastive learning for data-efficient deep learning from electrocardiographic images

Veer Sangha, Akshay Khunte, Greg Holste, Bobak J. Mortazavi, Zhangyang Wang, Evangelous K. Oikonomou EK, Rohan Khera

Journal of the American Medical Informatics Association. April 2024.

Real-world evaluation of an algorithmic machine-learning-guided testing approach in stable chest pain: a multinational, multicohort study

Oikonomou EK, Aminorroaya A, Dhingra LS, Partridge C, Velazquez EJ, Desai NR, Krumholz HM, Miller EJ, Khera R

European Heart Journal - Digital Health. April 2024.

A Multimodal Video-Based AI Biomarker for Aortic Stenosis Development and Progression

Oikonomou EK, Holste G, Yuan N, Coppi A, McNamara RL, Haynes NA, Vora AN, Velazquez EJ, Li F, Menon V, Kapadia SR, Gill TM, Nadkarni GN, Krumholz HM, Wang Z, Ouyang D, Khera R

Jama Cardiology. April 2024.

Comparative Effectiveness of Second-line Antihyperglycemic Agents for Cardiovascular Outcomes: A Large-scale, Multinational, Federated Analysis of the LEGEND-T2DM Study

Khera R, Aminorroaya A, Dhingra LS, Thangaraj PM, Camargos AP, Bu F, Ding X, Nishimura A, Anand TV, Arshad F, Blacketer C, Chai Y, Chattopadhyay S, Cook M, Dorr DA, Duarte-Salles T, DuVall SL, Falconer T, French TE, Hanchrow EE, Kaur G, Lau WC, Li J, Li K, Liu Y, Lu Y, Man KK, Matheny ME, Mathioudakis N, McLeggon JA, McLemore MF, Minty E, Morales DR, Nagy P, Ostropolets A, Pistillo A, Phan TP, Pratt N, Reyes C, Richter L, Ross J, Ruan E, Seager SL, Simon KR, Viernes B, Yang J, Yin C, You SC, Zhou JJ, Ryan PB, Schuemie MJ, Krumholz HM, Hripcsak G, Suchard MA

medRxiv. February 2024.

Severe aortic stenosis detection by deep learning applied to echocardiography

Gregory Holste, Evangelos K Oikonomou, Bobak Mortazavi, Andreas Coppi, Kamil F. Faridi MD, Edward J. Miller, John K. Forrest, Robert L. McNamara, Lucila Ohno-Machado, Neal Yuan, Aakriti Gupta, David Ouyang, Harlan M. Krumholz, Zhangyang Wang, Rohan Khera

European Heart Journal. November 2023.

An explainable machine learning-based phenomapping strategy for adaptive predictive enrichment in randomized clinical trials

Evangelos K. Oikonomou, Phyllis M. Thangaraj, Deepak L. Bhatt, Joseph S. Ross, Lawrence H. Young, Harlan M. Krumholz, Marc A. Suchard & Rohan Khera

NPJ Digital Medicine. November 2023.

Multinational patterns of second line antihyperglycaemic drug initiation across cardiovascular risk groups: federated pharmacoepidemiological evaluation in LEGEND-T2DM

Rohan Khera, Lovedeep Singh Dhingra, Arya Aminorroaya, Kelly Li, Jin J Zhou, Faaizah Arshad, Clair Blacketer, Mary G Bowring, Fan Bu, Michael Cook, David A Dorr, Talita Duarte-Salles, Scott L DuVall, Thomas Falcone, Tina E French, Elizabeth E Hanchrow, Scott Horban, Wallis Cy Lau, Jing Li, Yuntian Liu, Yuan Lu, Kenneth Kc Man, Michael E Matheny, Nestoras Mathioudakis, Michael F McLemore, Evan Minty, Daniel R Morales, Paul Nagy, Akihiko Nishimura, Anna Ostropolets, Andrea Pistillo, Jose D Posada, Nicole Pratt, Carlen Reyes, Joseph S Ross, Sarah Seager, Nigam Shah, Katherine Simon, Eric Yf Wan, Jianxiao Yang, Can Yin, Seng Chan You, Martijn J Schuemie, Patrick B Ryan, George Hripcsak, Harlan Krumholz, Marc A Suchard

BMJ Medicine. October 2023.

CarDS-Plus ECG Platform: Development and Feasibility Evaluation of a Multiplatform Artificial Intelligence Toolkit for Portable and Wearable Device Electrocardiograms

Sumukh Vasisht Shankar, Evangelos K Oikonomou, Rohan Khera

Medrxiv. October 2023.

Deep Learning-enabled Detection of Aortic Stenosis from Noisy Single Lead Electrocardiograms

Arya Aminorroaya, Lovedeep S Dhingra, Veer Sangha, Evangelos K Oikonomou, Akshay Khunte, Sumukh Vasisht Shankar, Aline Pedroso Camargos, Norrisa A Haynes, Ira Hofer, David Ouyang, Girish N. Nadkarni, Rohan Khera

Medrxiv. October 2023.

Machine learning in precision diabetes care and cardiovascular risk prediction

Evangelos K Oikonomou, Rohan Khera

Cardiovascular Diabetology. September 2023.

Cardiovascular Care Innovation through Data-Driven Discoveries in the Electronic Health Record

Lovedeep Singh Dhingra, Miles Shen, Anjali Mangla, Rohan Khera

The American Journal of Cardiology. September 2023.

Use of Smart Devices to Track Cardiovascular Health Goals in the United States

Arya Aminorroaya, Lovedeep S Dhingra, Arash A Nargesi, Evangelos K Oikonomou, Harlan M Krumholz, Rohan Khera

JACC: Advances. September 2023.

Detection of Left Ventricular Systolic Dysfunction from Electrocardiographic Images

Veer Sangha, Arash A Nargesi, Lovedeep S Dhingra, Akshay Khunte, Bobak J Mortazavi, Antônio H Ribeiro, Evgeniya Banina, Oluwaseun Adeola, Nadish Garg, Cynthia A Brandt, Edward J Miller, Antonio Luiz J Ribeiro, Eric J Velazquez, Luana Giatti, Sandhi M Barreto, Murilo Foppa, Neal Yuan, David Ouyang, Harlan M Krumholz, Rohan Khera.

Circulation. July 2023.

Detection of left ventricular systolic dysfunction from single-lead electrocardiography adapted for portable and wearable devices

Akshay Khunte, Veer Sangha, Evangelos K. Oikonomou, Lovedeep S. Dhingra, Arya Aminorroaya, Bobak J. Mortazavi, Andreas Coppi, Cynthia A. Brandt, Harlan M. Krumholz & Rohan Khera

NPJ Digital Medicine. July 2023.

Use of Wearable Devices in Individuals With or at Risk for Cardiovascular Disease in the US, 2019 to 2020

Lovedeep S. Dhingra, Arya Aminorroaya, MD, Evangelos K. Oikonomou, Arash Aghajani Nargesi, Francis Perry Wilson, Harlan M. Krumholz, Rohan Khera

JAMA Network Open. June 2023.

Persistence on Novel Cardioprotective Antihyperglycemic Therapies in the United States

Arash A Nargesi, Callahan Clark, Arya Aminorroaya, Lian Chen, Mengni Liu, Abraham Reddy, Samuel Amodeo, Evangelos K Oikonomou, Marc A Suchard, Darren K McGuire, Zhenqiu Lin, Silvio Inzucchi, Rohan Khera

The American Journal of Cardiology. June 2023.

Nonexercise machine learning models for maximal oxygen uptake prediction in national population surveys

Yuntian Liu, Jeph Herrin, Chenxi Huang, Rohan Khera, Lovedeep Singh Dhingra, Weilai Dong, Bobak J Mortazavi, Harlan M Krumholz, Yuan Lu

Journal of the American Medical Informatics Association. March 2023.

Time in Therapeutic Range for Targeted Temperature Management and Outcomes Following Out-of-Hospital Cardiac Arrest

Kevin M Wheelock, Paul S Chan, Lian Chen, James A de Lemos, P Elliott Miller, Brahmajee K Nallamothu, Saket Girotra, Rohan Khera

Resuscitation. January 2023.

Study Protocol for the Pilot Evaluation for SMartphone-adaptable Artificial Intelligence for PRediction and DeTection of Left Ventricular Systolic Dysfunction (The SMART-LV Pilot Study Protocol)

Lovedeep Singh Dhingra, Arya Aminorroaya, Veer Sangha, Akshay Khunte, Evangelos K Oikonomou, Bobak J Mortazavi, Robert McNamara, Jeph Herrin, Francis P Wilson, Harlan M Krumholz, Rohan Khera

medRxiv. January 2023.

Individualising intensive systolic blood pressure reduction in hypertension using computational trial phenomaps and machine learning: a post-hoc analysis of randomised clinical trials

Evangelos K Oikonomou, Erica S Spatz, Marc A Suchard, Rohan Khera

The Lancet Digital Health. November 2022.

Winner of the Robert Levy Memorial Lecture and Lifestyle and Cardiometabolic Health Early Career Investigator Award, 2021

Contemporary National Patterns of Eligibility and Use of Novel Lipid‐Lowering Therapies in the United States

Miles Shen, Arash A. Nargesi, Khurram Nasir, Deepak L. Bhatt and Rohan Khera

Journal of the American Heart Association. September 2022.

County-level variation in cardioprotective antihyperglycemic prescribing among medicare beneficiaries

Jonathan Hanna, Arash A Nargesi, Utibe R. Essien, Veer Sangha, Zhenqiu Lin, Harlan M Krumholz, Rohan Khera

The American Journal of Preventive Cardiology. September 2022.

Specialty Visits and Real-world Initiation of Cardioprotective Anti-hyperglycemic Medications Among US Adults with Type 2 Diabetes

Arash A Nargesi, Callahan Clark, Mengni Liu, Abraham Reddy, Samuel Amodeo, Rohan Khera

medRxiv. May 2022.

Automated multilabel diagnosis on electrocardiographic images and signals

Veer Sangha, Bobak J. Mortazavi, Adrian D. Haimovich, Antônio H. Ribeiro, Cynthia A. Brandt, Daniel L. Jacoby, Wade L. Schulz, Harlan M. Krumholz, Antonio Luiz P. Ribeiro & Rohan Khera

Nature Communications. March 2022.

A multicenter evaluation of computable phenotyping approaches for SARS-CoV-2 infection and COVID-19 hospitalizations

Rohan Khera, Bobak J. Mortazavi, Veer Sangha, Frederick Warner, H. Patrick Young, Joseph S. Ross, Nilay D. Shah, Elitza S. Theel, William G. Jenkinson, Camille Knepper, Karen Wang, David Peaper, Richard A. Martinello, Cynthia A. Brandt, Zhenqiu Lin, Albert I. Ko, Harlan M. Krumholz, Benjamin D. Pollock & Wade L. Schulz

npj Digital Medicine. March 2022.

Phenomapping-Derived Tool to Individualize the Effect of Canagliflozin on Cardiovascular Risk in Type 2 Diabetes

Evangelos K. Oikonomou, Marc A. Suchard, Darren K. McGuire, Rohan Khera

Diabetes Care. February 2022.

Winner of the Northwestern Cardiovascular Young Investigators' Forum Clinical Fellows’ Award, 2021

Patterns of Medication Use and Prescription Fills for Cardioprotective Anti-Hyperglycemic Agents in the United States

Arash A Nargesi, Callahan Clark PharmD, Lian Chen, Mengni Liu, Abraham Reddy, Samuel Amodeo, Evangelos K Oikonomou, Marc A Suchard, Darren K McGuire, Zhenqiu Lin, Silvio Inzucchi, Rohan Khera

medRxiv. February 2022.

Clinician Trends in Prescribing Direct Oral Anticoagulants for US Medicare Beneficiaries

Kevin M. Wheelock, Joseph S. Ross, Karthik Murugiah, Zhenqiu Lin, Harlan M. Krumholz, Rohan Khera

JAMA Network Open. December 2021.

Patterns of Prescribing Sodium-Glucose Cotransporter-2 Inhibitors for Medicare Beneficiaries in the United States

Veer Sangha, Kasia Lipska, Zhenqiu Lin, Silvio E Inzucchi, Darren K McGuire, Harlan M Krumholz, Rohan Khera

Circulation: Cardiovascular Quality and Outcomes. November 2021.

A phenomapping-derived tool to personalize the selection of anatomical vs. functional testing in evaluating chest pain (ASSIST)

Evangelos K Oikonomou, David Van Dijk, Helen Parise, Marc A Suchard, James de Lemos, Charalambos Antoniades, Eric J Velazquez, Edward J Miller, Rohan Khera

European Heart Journal. July 2021.

An Evaluation of the Vulnerable Physician Workforce in the United States During the Coronavirus Disease-19 Pandemic

Rohan Khera, Lovedeep Singh Dhingra, Snigdha Jain, Harlan M Krumholz

Journal of General Internal Medicine. June 2020.